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CaptionDuke University has received a two-year, $3 million grant from the Bill & Melinda Gates Foundation to study resistance to HIV infection among people with hemophilia.
The study, to be conducted at the Center for Human Genome Variation at Duke’s Institute for Genome Sciences & Policy, will build upon a growing body of evidence that may help explain why some people are able to fend off infection, even when repeatedly exposed to HIV, a phenomenon known as host resistance. Center Director David Goldstein, PhD, will lead the investigation in collaboration with Kevin Shianna, PhD, and Jacques Fellay, M.D., PhD.
Host resistance is present only in a small percentage of the general population. It can be traced, in part, to the presence of genetic variants linked to the ability to block infection.
“But these known variants explain only a very small amount of the differences among individuals exposed to the HIV virus,” says Goldstein. “We think there are probably other, much rarer variants that also play a role. We just haven’t had the right tools to find them, but now we do.”
Goldstein says rare variants are more likely to be found in a narrow population where people share unique or extreme characteristics – like patients with hemophilia who have been heavily exposed to HIV-contaminated blood products. Hemophilia patients were often exposed to HIV-infected blood products in the 1970s and 1980s before safety measures were undertaken to screen out tainted blood. While most of these patients became infected and died of AIDS, a significant minority did not.
“Interestingly, previous studies have shown that such individuals are 15 times more likely to carry a specific genetic variant linked to resistance (a deletion in the HIV main co-receptor CCR5) than is a person in the general population,” added Goldstein. “That enrichment for a known protective genetic factor tells us that HIV-exposed yet uninfected individuals with hemophilia form an ideal study group.”
The support from the Gates Foundation will enable Goldstein, Shianna and Fellay to use high-throughput sequencing technology to resequence the genome of 50 individuals with hemophilia. The study group, assembled by researchers in Duke’s Center for HIV/AIDS Vaccine Immunology (CHAVI), is composed of individuals with a documented history of treatment with contaminated factor VIII concentrate between 1979 and 1984, but who did not contract HIV.
The goal is to discover rare variants enriched in the genome of these carefully selected individuals. Researchers hope that will enable them to identify which variants are most likely associated with resistance to HIV infection.
“We hope this project will yield new information that will help us to further understand disease resistance and to identify new targets and guidance for drug and vaccine development,” says Goldstein. “Rare human genetic variation is a new frontier for discovery and I am grateful to the Bill & Melinda Gates Foundation for enabling us to develop it here at Duke.”
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By Mailer on 01/15 11:13 AM
An additional seawater water treatment plant will be launched in mid 2009, bringing the total daily capacity of both facilities to 64,000 cubic metres, the firm said. The treatment projects are part of an agreement that will hand over ownership and ongoing stewardship responsibilities for the water and sewage infrastructure of Palm Jumeirah to Palm Water, Palm Utilities’ water utility division. Sewage collection, treatment and transportation, along with distribution of drinking water, irrigation and fire fighting water and industrial water and collection of chiller blowdown water are among the areas of work Palm Water will carry out under the agreement. Palm Utilities has also revealed plans to pursue new business ventures within other utilities including sustainable energy and environmental waste management. In addition, the company said it was looking to expand its operations overseas and had initiated talks for new business prospects with potential partners in the Middle East, India and the rest of Asia. Palm Utilities was set up in 2007 by Istithmar World, the investment arm of the Dubai World group of companies, a government-owned conglomerate which also includes Nakheel, the developer of the three Palm islands.
By apostle shada mishe on 11/24 05:48 PM
THE CURE for HIV/AIDS.......AMBUSH
THE IDEA that AMBUSH cures AIDS
is being proven by the more than 400 individuals who have taken a dose of 60 ml three times daily for 21 days. The result is that AMBUSH ‘KILLS’ the virus by causing the protein envelope to rupture and the viral particles are discarded by the white blood cells. AMBUSH is able to ‘KILL’ the virus that are ‘hiding’ in the lymph system by its ‘natural radioactive’ properties. This process allows the body to ‘return to normal health’ with a corresponding immunity to that or those strains of the virus.
What is AMBUSH ?
AMBUSH is a radioactive isotope of uranium that is found in the ‘palm’ plant of which there are more than 3000 species. When ingested, AMBUSH causes the body temperature in the trunk area to rise to about 102 degrees when the individual is sleeping. The preparation takes four hours per batch, which is then given to the individuals for consumption 60 ml three times daily for 21 days. AMBUSH is a herbal preparation in this form but it contains an active ingredient which is a ‘NEW’ crystalline substance, a drug from the ‘palm plant’ similarly to ASPIRIN originating from the willow tree bark
RESULTS:
After 21 days on AMBUSH, ALL the individuals experienced a decrease in viral load to undetectable, an increase in cd4, increase in RBC, an improvement in general health such as more color to the face, decrease in Buffalo hump, an increase in gluteal muscles, a decrease to having no joint pains whereby individuals can bend to touch their toes, and walk up steps are but a few examples. There is also a dramatic increase in their sexual appetite beginning after the first week of therapy
DISCUSSION:
In any plant concoction such as percolated ‘tea’, there are 30-40,000 compounds, whi ch would take the scientific community twenty years to isolate one particular ingredient if they knew what they were looking for. The LORD GOD has given me seven steps to isolate the active ingredient, which is soft and metallic in nature and has a carbon- uranium-sulfur-(classified)-phentolamine configuration or structure. This is similar to Federick Kekule and the discovery of the benzene ring where he dreamt the structure.
As an antiviral and ‘natural radioactivity’ producing agent, AMBUSH is also effective against leukemia, lupus and HPV. Here I am saying that I have ‘GIVEN’ AMBUSH in the same ‘strength’ and dosage to patients with leukemia, lupus and HPV. A 35 year old male with HIV found it difficult to impossible to urinate was put on ‘green tea’ and water while the doctors contemplated prostrate surgery. One of the doctors gave him my number , I sent him a supply of AMBUSH an d he has not been given any more ARV’s, since taking AMBUSH 18 months ago, is in ‘good’ health and has expressed a willingness to be examined by HIV investigators like many others who have taken AMBUSH.
I have sent this ‘IDEA’ to most HIV research agencies, scientist of the field, universities, hospitals, clinics, politicians and news agencies to which it is REJECTED because the name of THE LORD GOD is mentioned. He has steered me scientifically through the processes such as which plant and how to produce the active ingredient. What are the odds of a Florida Pharmacist picking a plant would contain the CURE for HIV/AIDS ?
I have never charged any of the people for their supply of AMBUSH but a life saving has been spent on the project with NO renumeration from any sources because AMBUSH falls outside the walls of modern medicine and research.
PROPOSAL:
My proposal is that I PROVE that AMBUSH CURES HIV/AIDS by giving it to a number of END-STAGE or DRUG-RESISTANT people and the scientific community watches their recovery. This proposal addresses the problem in that I have already outlaid the results to be obtained.
This IDEA is unconventional in that the scientific community has rejected AMBUSH because I say it is GOD given. Secondly if I wrote it according to certain standards, then it might be peer reviewed. However, THE LORD GOD has also shown me that there are five enzyme systems associated with the virus, reverse transcriptase, protease, fusion and two more of which causes the virus to be AIRBOURNE. This means that without DIVINE intervention mankind and ALL warm- blooded mammals will be extinct in a number of years.
The PROOF of what I am saying is found in scientific papers wherein it is found that when the protease cuts the viral strands, it cuts it at DIFFERENT lengths EVERY time, to which it should always be a valine at the end but is a different amino acid every time. This is why it is IMPOSSIBLE to produce a VACCINE.
Since this is NOT a hypothesis but there are about 400 individuals who have taken AMBUSH, here lies a vast area in which to check, recheck and confirm that AMBUSH CURES AIDS. Let it be mentioned that during the HIV reproductive cycle, reverse transcriptase converts viral RNA into DNA compatible to human genetic materials. Thus the human DNA has been ‘hijacked’ and since each person has a DIFFERENT DNA, then the new viral copy is unique to that person which shows that each individual has a DIFFERENT STRAIN of the virus. Consider two HIV positive people swapping viral strains and increasing its complexity with multiple partners.
It can also be proposed that they be revisited as proof that the strain or strains that they had were ‘killed’ at the time of taking AMBUSH considering that a person can catch as many different strains as there are people who are infected by HIV.
I am also willing to work with the scientific community in identifying those individuals who took AMBUSH and wish to be identified with this process notwithstanding that some are stigmatized while others are jubilant,
Once AMBUSH is verified as being able to accomplish that which is aforementioned then the next stage might be the natural and artificial synthesis of the substance.
Finally, if this is accepted or not, believed or not, THE LORD GOD always wins and this is the heavenly truth to which AMBUSH was divinely given to mankind for the CURE of HIV/AIDS and it will be here forever. Apostle Shada Mishe.
Here is a video taped presentation that I gave at t he Martin Luther King library in Washington
http://www.youtube.com/watch?v=8V53D1w__Po
http://www.youtube.com/watch?v=vPwuwlVBOV0
http://www.youtube.com/watch?v=ZejptOwMTzQ
http://www.youtube.com/watch?v=CqcTgIAhrhc
http://www.youtube.com/watch?v=f7HPKcT_iwY
http://www.youtube.com/watch?v=W9iQfgiYAnw
http://www.youtube.com/watch?v=i3RzRS6tJDM
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